Here is how to have two different Sonarr instances (for example 4k and standard deff). Change the location after --data= to wherever you want the data to be.

Since lidarr/radarr are both based on sonarr I would assume you could do it the same way with those as well.

nano /etc/systemd/system/sonarr.service

[Unit]
Description=Sonarr Daemon
After=network.target

[Service]
User=plex
Group=plex
StandardOutput=null

Type=simple
ExecStart=/usr/bin/mono /opt/Sonarr/Sonarr.exe -nobrowser --data=/opt/DB/Sonarr
TimeoutStopSec=20
KillMode=process
Restart=on-failure

[Install]
WantedBy=multi-user.target

nano /etc/systemd/system/sonarr4k.service

[Unit]
Description=Sonarr Daemon
After=network.target

[Service]
User=plex
Group=plex
StandardOutput=null

Type=simple
ExecStart=/usr/bin/mono /opt/Sonarr/Sonarr.exe -nobrowser --data=/opt/DB/Sonarr4k
TimeoutStopSec=20
KillMode=process
Restart=on-failure

[Install]
WantedBy=multi-user.target

Now we need to reload, enable, and start both services

systemctl daemon-reload systemctl enable sonarr sonarr4k –now