I was trying to get an alias to work with a ProxyPass. This is pretty easy in NGiNX you just add locations where they need to be, but it appears in Apache/HTTPD you have to specify to ignore the location without the ProxyPass Module

The below needs to be added into your VirtualHost. This specific use was for the AppRise_API server

  Alias "/s" "/opt/apprise/server/apprise_api/static"

  <Directory "/opt/apprise/server/apprise_api/static">
  AllowOverride None
  Require all granted

  ReWriteEngine on
  ProxyPassMatch ^/s !
  ProxyPass "/"  "http://localhost:8000/"
  ProxyPassReverse "/"  "http://localhost:8000/"

This show me why I love NGiNX so much more than apache